Hike from June to September, once the highland routes and mountain roads are open; outside that the interior is a full winter expedition.
Base at the Landmannalaugar hut area (reached by highland bus or a 4x4 that can ford rivers) for the shorter peaks, or hike Fimmvörðuháls as a through-route between Skógar and Þórsmörk. Book hut bunks ahead in peak weeks or carry a tent.
Bring proper boots, waterproofs, warm layers, food, and a map and compass — cloud and cold are the real hazards, not the terrain's difficulty. Check the mountain forecast and river levels, start early, and be ready to turn back.
No guide is needed for fit, prepared walkers, but never underestimate highland weather.